Stream Leader: David Stroud
Meng-Qiu Dong – Associate Investigator, National Institute of Biological Sciences (NIBS), Beijing. Improving Mass-Spectrometry Analysis of Protein Structures with Arginine-Specific Chemical Cross-linkers.
Meng-Qiu Dong obtained her PhD at Yale University in 2001. Then, after six years of postdoc training in UCSD and in the Yates lab of the Scripps Research Institute, she moved back to China near the end of 2007 to start her independent research at NIBS, Beijing. On the biology side, she is interested in understanding the secrets of aging using C. elegans as a model. On the mass spec front, her current focus is perfecting the technology of chemical cross-linking of proteins coupled with mass spectrometry (CXMS). She and collaborators have developed a complete CXMS workflow, which features the most inexpensive and readily available cross-linkers and the software program pLink for data analysis. CXMS is an effective tool for locating the interface between interacting proteins, and is gaining popularity in structural analysis of large protein complexes. She has extended the technology to mapping native disulfide bonds of proteins from simple or complex samples. Recently, she is collaborating with structural biologists to characterize protein dynamics using CXMS.
David James, Domain Leader for Biology at the Charles Perkins Centre, University of Sydney. Systems Biology, Precision Medicine and Metabolic Disease
Professor James currently holds the Leonard P Ullmann Chair in Molecular Systems Biology and he is the Domain Leader for Biology at the Charles Perkins Centre, University of Sydney. Professor James has made major contributions to our understanding of insulin action. In the late 1980s he published a series of journal articles in Nature describing the identification and characterization of the insulin responsive glucose transporter GLUT4. Professor James then focused his efforts on unveiling the cellular and molecular control of insulin-stimulated glucose transport. He has also made contributions in the area of SNARE proteins, signal transduction and more recently in systems biology. He has won several awards including the Glaxo Wellcome Medal for Medical Research and the Kellion medal for outstanding contributions to Diabetes research. In 2007 he was elected as a fellow of the Australian Academy of Science and was awarded the NSW Premier Prize in Excellence in Medical Biological Sciences in 2016. He is on the editorial board of a number of prestigious journals and he is regularly invited to speak at key international meetings on diabetes and metabolism.
Traude Beilharz, ARC: Future Fellow, Department of Biochemistry and Molecular Biology, Stem cells and Development division: Biomedicine Discovery Institute, Monash University. The integration of core metabolism with RNA processing.
Traude’s research team consists of wet-lab and computational researchers who together to study the eukaryotic RNA metabolism. Specifically, they focus on the role of 3’-end dynamics in post-transcriptional gene regulation. Through the combined use of high content, next generation technologies and evolutionary conservation in model organisms, Traude’s team aim to accelerate the discovery of gene-function, and to understand how gene inactivation effects RNA regulatory networks in quantitative terms. During this discovery process, Traude’s personal ambition is improve the lay understanding of future genetics and genomics, as well as to train future researchers in the use of computational tools required to leverage the rapid advances in big-data driven science.