Stream Leader: David Stroud
Meng-Qiu Dong – Associate Investigator, National Institute of Biological Sciences (NIBS), Beijing. Improving Mass-Spectrometry Analysis of Protein Structures with Arginine-Specific Chemical Cross-linkers.
Meng-Qiu Dong obtained her PhD at Yale University in 2001. Then, after six years of postdoc training in UCSD and in the Yates lab of the Scripps Research Institute, she moved back to China near the end of 2007 to start her independent research at NIBS, Beijing. On the biology side, she is interested in understanding the secrets of aging using C. elegans as a model. On the mass spec front, her current focus is perfecting the technology of chemical cross-linking of proteins coupled with mass spectrometry (CXMS). She and collaborators have developed a complete CXMS workflow, which features the most inexpensive and readily available cross-linkers and the software program pLink for data analysis. CXMS is an effective tool for locating the interface between interacting proteins, and is gaining popularity in structural analysis of large protein complexes. She has extended the technology to mapping native disulfide bonds of proteins from simple or complex samples. Recently, she is collaborating with structural biologists to characterize protein dynamics using CXMS.