Conveners
Concurrent Session 4: Structural Biology II - Sponosred by DECTRIS
- Jade Forwood ()
Prof.
Emily Parker
(University of Canterbury)
25/11/2016, 13:30
Structural Biology
Oral
We have used protein crystallography and small angle X-ray scattering to understand the way that enzymes respond to remote signals – a process known as allostery (from the Greek *allos* meaning “other” and *stereos* meaning “solid”). Allostery is critical to the control of metabolism, and although allostery has been known for many years, it is only more recently that the molecular networks...
Dr
Jason Paxman
(La Trobe University)
25/11/2016, 14:00
Structural Biology
Oral
Autotransporter proteins are the largest group of outer membrane and secreted virulence factors from important bacterial pathogens such as Salmonella enterica, Shigella flexneri, Neisseria meningitidis and pathogenic E. coli strains. They are important contributors to bacterial pathogenesis, functioning as toxins, adhesins and facilitators of biofilm formation. Their importance to human...
Dr
Daniel Eriksson
(Australian Synchrotron)
25/11/2016, 14:15
Structural Biology
Oral
The micro-crystallography beamline, MX2, depends on three mirror elements for conditioning and focussing the beam at the sample position. One of these, the Microfocussing Horizontally Focussing Mirror (MHFM) is showing signs of beam damage. A likely source of this damage is the high-voltage piezo bender bimorph system used to shape the mirror.
This manifests as significant structure in the...
Dr
Jakub Gruszczyk
(The Walter and Eliza Hall Institute)
25/11/2016, 14:30
Structural Biology
Oral
Understanding the process of invasion is essential for developing strategies to stop blood stage infection. An important feature of *Plasmodium* invasion is the host cell selectivity that the different species have for cells of the erythroid lineage. Indeed, *Plasmodium vivax* preferentially invades reticulocytes which are immature red blood cells. Several members of *P. vivax* Reticulocyte...
Prof.
Alice Vrielink
(University of Western Australia)
25/11/2016, 14:45
Structural Biology
Oral
Multiple drug resistance (MDR) in Gram-negative bacteria represents one of the most intractable problems facing modern medicine. Colistin and polymyxin are cationic antimicrobial peptide antibiotics which permeabilise the bacterial outer membrane and have been used to treat infections. Resistance to these antibiotics is conferred by the modification of the lipid A headgroups with...
Tom Caradoc-Davies
(Australian Synchrotron.)
25/11/2016, 15:00
Structural Biology
Oral
The advent of the Eiger family of detectors has pushed the speed of MX experiments to new heights with SAD phasing datasets being collected in as little as 1 second. The Eiger16M can produce 10Tb of data per day at a bandwidth of 40Gb/s. These high data rates come with a range of benefits and challenges for synchrotron facilities. With an Eiger 16M detector scheduled for delivery in December...
