25-27 November 2015
National Centre for Synchrotron Science
Australia/Melbourne timezone

Nanoparticle Dose Enhancement of Synchrotron Beams on the IMBL

26 Nov 2015, 11:30
NCSS Seminar Room ()

NCSS Seminar Room

Oral Radiotherapy and Radiobiology Radiotherapy and Radiobiology


Mr Frank Gagliardi (William Buckland Radiotherapy Centre)


Nanoparticles with high atomic number (Z) have a larger x-ray cross section than biological tissues. Synchrotron beams interact with the nanoparticles to produce Auger electrons which deposit their energy over a short range, typically less than a micron. This characteristic offers the ability to enhance the dose delivered to tumors by synchrotron broad beam (BB) or microbeam radiation therapy (MRT). High Z nanoparticles can also be used as a contrast agent for in-vivo x-ray imaging during the treatment setup. Here we present our initial findings on the dose enhancement effect for synchrotron beams on the IMBL using UV/Vis spectroscopy with radiosensitive dosimeters irradiated with and without nanoparticles.
Keywords Nanoparticles, Dose Enhancement, IMBL

Primary author

Mr Frank Gagliardi (William Buckland Radiotherapy Centre)


Dr Andrew Stevenson (Australian Synchrotron/ CSIRO) Prof. Moshi Geso (RMIT University) Prof. Rick Franich (RMIT University)

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