Conveners
Topical Session 5: Biology
- Kathleen Wood (Australian Nuclear Science and Technology Organisation)
Human carbonic anhydrase IX (CA IX) expression is activated by hypoxic condition in aggressive, metastatic tumors. Cancer patietns positive for CA IX have generally a poor prognosis. CA IX has emerged as an important cancer target, but efforts to develop isoform selective inhibitors are complicated by the presence of 14 other CA isoforms that share high sequence and structural similarity. This...
Correctly forming disulphide bonds is critical to the folding of a wide variety of proteins. Bacterial virulence factors are one class of proteins containing disulfide bonds, thus, an approach to disarm virulent bacterial might involve shutting down the machinery involved in the formation of disulfide bonds. The suppressor of copper sensitivity (Scs) proteins form part of the disulfide bond...
To date, epidemiological studies, animal studies and clinical trials have indicated the potential of non-steroidal anti-inflammatory drugs (NSAIDs) for the chemoprevention of colorectal cancer (CRC) [1]. Unfortunately, the use of NSAIDs for CRC chemoprevention is significantly limited due to the severe gastrointestinal (GI) side effects that have been associated with their long term use [1]....
Plant cell walls (PCWs) are extremely complex structures in which cellulose microfibrils are hierarchically assembled and embedded in a multi-component matrix. While the cellulose microfibrils represent the basic building unit providing mechanical strength [1], the matrix components are able to tune the properties of each specific tissue [2-3], increasing the flexibility or limiting the...