ANBUG-AINSE Neutron Scattering Symposium, AANSS 2018

Interaction of cinnamic acid and its analogues with Pluronic® micelles

Not scheduled

1h 30m

AINSE Conference Centre New Illawarra Road Lucas Heights NSW 2234 Australia

Poster Biology Poster Session

Speaker

Mr VIJAY PATEL (J. N. M. PATEL SCIENCE COLLEGE, BHARTHANA (VESU), SURAT-395017, GUJARAT, INDIA)

Description

The interaction of cinnamic acid (CA) and its analogues viz. p-coumaric acid (PCA) and caffeic acid (CFA) with core-shell micelles of a moderately hydrophobic Pluronic® P123 has been investigated using cloud point (CP), viscosity, dynamic light scattering (DLS), small-angle neutron scattering (SANS) and steady-state fluorescence measurements. These solubilizates alter micellar behaviour of copolymer solution dependant on their hydrophobicity. P123 micelles exhibit time-dependent restructuring and growth processes and at different rates which is pH dependent and responsive to the presence of a salt. Observed results demonstrate that restructuring and growth of polymer micelles can be tuned with ease upto a substantial extent just by changing the concentration of the additives and the pH of the solution. Considering the medical applications of cinnamic acid and its analogues and of Pluronic® in drug delivery systems, the present study can provide important insight of the possible time-dependant delivery mechanism of drugs.