- Victor Streltsov (CSIRO)
77. XFM mapping of elemental distributions in brain stem sections from multiple sclerosis patients using the BioMaia detector
Dr Rachel Mak (University of Sydney)
Locus ceruleus (LC) neurons supply central nervous system cells with noradrenaline, and damage to the LC has been found in multiple sclerosis (MS) and in neurodegenerative diseases such as Alzheimer’s disease. LC neurons selectively accumulate heavy metal toxicants, which could play an important role in the pathogenesis of these diseases. Histochemical studies of brain tissue from MS patients...
Dr Nicholas Reynolds (Swinburne University of Technology)
Amyloid fibrils are implicated in over 20 neurodegenerative diseases. The mechanisms of fibril structuring and formation are not only of medical and biological importance but are also relevant for material science and nanotechnologies due to the unique structural and physical properties of amyloids. We found that hen egg white lysozyme (HEWL), homologous to the disease-related human lysozyme,...
80. Synchrotron FTIR microspectroscopy coupled with Principal Component Analysis shows evidence for the cellular bystander effect
Dr Keith R Bambery (Infrared Microscopy Beamline, Australian Synchrotron)
Synchrotron Radiation - Fourier Transform Infrared (SR-FTIR) microscopy coupled with multivariate data analysis was used to monitor the radiation induced cellular bystander effect. Living prostate cancer PC-3 cells were singly irradiated with various numbers of protons, ranging from 50-2000, with an energy of either 1 or 2 MeV using a proton microprobe. SR-FTIR spectra of cells, fixed after...
Dr Mark Tobin (Australian Synchrotron)
Attenuated Total Reflection (ATR) is a sampling method frequently used for FTIR microanalysis of samples which cannot be prepared as thin sections for transmission analysis. Generally, an ATR prism is attached to the front of the microscope objective and 2D mapping achieved by repeated contacts with the ATR crystal. The method is more suited to harder materials, since the multiple ATR...