25-27 November 2015
National Centre for Synchrotron Science
Australia/Melbourne timezone

Supramolecular interactions in organoamidoplatinum(II) anticancer compound

27 Nov 2015, 13:30
National Centre for Synchrotron Science

National Centre for Synchrotron Science

Australian Synchrotron 800 Blackburn Road Clayton VIC 3168
Board: BS-08
Poster Biological Systems Poster Session 2


Mrs Ruchika Ojha (student)


The investigation of the crystal packing of organoamidoplatinum(II) [Pt(p-YC6F4)NCH2CH2NR'2(py)X] (Y = H, F, Br; R'= Et or Me; X = Cl, Br, I) anticancer compounds show supramolecular interactions in the solid state which include intermolecular H bonding and π-π interactions. The supramolecular interactions mainly depend on the nature of the alkyl groups (methyl/ethyl) present on the amine N. The crystal packing is similar for the compounds having same alkyl groups if a small substituent (H or F) is in the para position of the polyfluoroaryl ring, but the presence of bulky substituent like Br in the para position of the polyfluoroaryl ring changes the crystal packing. Due to the difference in crystal packing, H-bonding is slightly different for –NEt2 and –NMe2 compounds. ![enter image description here][1] [1]: https://dl.dropboxusercontent.com/u/33905914/AOFSAR.tif Figure 1. X-ray crystal structure of Pt{(p-HC6F4)NCH2CH2NEt2}Cl(py)] (a) showing asymmetric unit. Hydrogen atoms are omitted for clarity and thermal ellipsoids are displayed at the 50% probability level. (b) showing H…F bonding (c) showing unit cell with H-bonding and π-π interactions between the polyfluoroaryl ring planes and between the pyridine planes.
Keywords Platinum anticancer agents, supramolecular interactions, H bonding

Primary authors

Prof. Alan Bond (Monash University) Prof. Glen Deacon (Monash University) Prof. Peter Junk (James Cook University) Mrs Ruchika Ojha (student)

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