Conveners
Concurrent Session 2: Structural Biology I - Sponsored by DECTRIS
- Begoña Heras ()
Prof.
Colin Jackson
(Australian National University)
24/11/2016, 13:30
Structural Biology
Oral
Enzymes must be ordered to allow the stabilization of transition states by their active sites, yet dynamic enough to adopt alternative conformations suited to other steps in their catalytic cycles. The biophysical principles that determine how specific protein dynamics evolve and how remote mutations affect catalytic activity are poorly understood. Here we examine a 'molecular fossil record'...
Dr
Kelan Chen
(Walter and Eliza Hall Institute)
24/11/2016, 14:00
Structural Biology
Oral
Structural Maintenance of Chromosomes flexible Hinge Domain-containing 1 (SMCHD1) is a non-canonical SMC protein that plays critical roles in epigenetic regulation. Recently, heterozygous loss of function mutations in *SMCHD1* were identified in facioscapulohumeral muscular dystrophy (FSHD) patients, leading to failure of epigenetic silencing of the disease-causing gene *DUX4* in muscle cells....
Dr
Anthony Duff
(ANSTO)
24/11/2016, 14:15
Structural Biology
Oral
Ezrin is member of the ERM (Ezrin-Radixin-Moesin) family of proteins that have been conserved through metazoan evolution. These proteins have dormant and active forms, where the latter links the actin cytoskeleton to membranes. ERM proteins have three domains: an N-terminal FERM (band Four-point-one ERM) domain comprising three subdomains (F1, F2 and F3); a helical domain; and a C-terminal...
Dr
Jason Price
(Australian Synchrotron)
24/11/2016, 14:30
Structural Biology
Oral
The macromolecular (MX) beamlines at the Australian synchrotron are mixed use between the structural biology and chemical crystallography (CX) communities. Since commissioning the high throughput MX1 bending magnet and the MX2 microfocus undulator beamlines have proven very successful for both communities.
With the transfer of the Australian Synchrotron under ANSTO as recognition as its...
Jade Forwood
(CSU)
24/11/2016, 14:45
Structural Biology
Oral
The assembly and regulation of viral capsid proteins into highly ordered macromolecular complexes is essential for viral replication. Recent reports have elucidated the ability of capsids to switch between T1 and T3 symmetry, however little is known regarding how capsid proteins can switch between smaller, non-icosahedral macromolecular complexes. Here we utilize crystal structures of the...
Ms
Radhika Mohandass
(RMIT)
24/11/2016, 15:00
Structural Biology
Oral
Radhika Mohandass1, Dilek Yalcin1, Calum Drummond1 Tamar Greaves1
1. School of Science, College of Science, Engineering and Health, RMIT University, Melbourne, VIC, Australia
Email: s3607967@student.rmit.edu.au
Ionic liquids (ILs) can have a stabilizing or destabilizing effect on proteins, which is strongly dependent on the cation and anion of the IL (1). Consequently ILs have...