Speaker
Mr
Liam Day
(Royal Melbourne Institute of Technology)
Description
**Introduction**
Synchrotron microbeam radiation therapy (MRT) is a novel radiotherapy modality with significant clinical potential. We have produced a simple dose calculation algorithm for MRT using the Eclipse Treatment Planning System (TPS), by Varian Medical Systems.
**Method**
The calculation engine in Eclipse was configured to directly evaluate ‘peak’ doses. Monte Carlo-simulated Peak-to-Valley Dose Ratios were used to obtain the ‘valley’ dose displayed in Eclipse. We compared dose profiles generated by Eclipse with Geant4 Monte Carlo simulations and measurements from the Imaging & Medical Beamline at The Australian Synchrotron. We also performed a plan comparison study using anonymised patient datasets, comparing kilovoltage MRT plans with clinical megavoltage treatment plans.
**Results**
The Eclipse TPS performed well in calculating ‘peak’ doses in a water phantom. Considering the simplicity of the algorithm, the ‘valley’ dose and field profiles were also produced with reasonable accuracy, albeit with some underestimation of the valley dose for larger field sizes.
Compared to the clinical megavoltage treatment plans, MRT plans demonstrated adequate target coverage whilst meeting normal tissue dose constraints when target volumes were small and relatively superficial. As expected, planning goals for deep seated tumours and target regions distal to bone could not be met using MRT.
**Conclusion**
There are real advantages to using the familiar environment of Eclipse with a new radiotherapy paradigm such as MRT. Although, there are limitations to our MRT calculation engine in Eclipse and further work is required, the data generated in this work are overall encouraging and indicate that the potential for this calculation engine to be implemented in the future as part of a Phase 1 clinical trial.
| Are you an ECR? (<5 yrs</br>since PhD/Masters) | No |
|---|---|
| Keywords or phrases (comma separated) | microbeam, radiotherapy, treatment planning |
| What is your gender? | Male |
| Are you a student? | Yes |
| Do you wish to take part in</br>the Student Poster Slam? | No |
Primary author
Mr
Liam Day
(Royal Melbourne Institute of Technology)
Co-authors
Dr
Christopher Poole
(University of Melbourne)
Prof.
Crister Ceberg
(Department of Radiation Physics, Lund University Hospital, Sweden)
Dr
Jeffrey CROSBIE
(RMIT University)
Mr
Lloyd Smyth
(University of Melbourne, Epworth HealthCare)
Ms
Madeleine Holm
(Department of Medical Radiation Physics, Lund University, Sweden)
Dr
Per Engström
(Department of Radiation Physics, Lund University Hospital, Sweden)
Prof.
Peter Rogers
(University of melbourne)
