Structural Biology I
- Brett Collins ()
Prof. James Holton (UCSF/LBNL)
The success or failure of any structure determination effort is dictated by the signal-to-noise ratio, so a quantitative understanding of both signal and noise is needed to have the best chance of success and to avoid wasted effort on samples that simply aren’t good enough. There are three main hurdles to every structure determination effort: the Phase Problem, the Amplitude Problem, and the...
Mr Jason Brouwer (Walter and Eliza Hall Institute of Medical Research)
Apoptotic stimuli activate and oligomerise the pro-apoptotic proteins Bak and Bax resulting in mitochondrial outer membrane permeabilisation and subsequent cell death. Crystal structures by Czabotar et al. (2013) provided novel insights into BH3-only induced Bax activation and oligomerisation, namely the separation of the core and latch domains, followed by core domain dimerisation. Here we...
Dr Julian Vivian (Monash University)
Abacavir hypersensitivity syndrome (AHS) is a T-cell mediated drug hypersensitivity triggered by the antiretroviral drug abacavir, used in the treatment of HIV infection. It is one of an increasing number of adverse drug reactions found to be associated with specific Human Leukocyte Antigen (HLA) alleles. Occuring exclusively in individuals possessing HLA-B*57:01, this is one of the strongest...
Dr Ruby Law (Monash University)
Plasminogen is a 7-domain protein (with an N-terminal Pan-apple domain, five kringle domains and a C-terminal serine protease domain) that adopts a closed, activation-resistant conformation in the circulatory system. The recruitment of plasminogen to its target sites is dependant on the lysine binding sites of the kringle domains. Binding to lysine residues on cell receptors and fibrin clots...