20-21 November 2014
National Centre for Synchrotron Science
Australia/Melbourne timezone
Save the date: User Meeting 2015 - 26-27 November

X-ray photoemission spectroscopy of radiosensitizers

20 Nov 2014, 17:30
1h 30m
NCSS Exhibition Area ()

NCSS Exhibition Area

Australian Synchrotron 800 Blackburn Road Clayton VIC 3168
Board: 305


Ms Mayanthi Goonewardanea (Swinburne)


Radiosensitizers are used in radiotherapy to enhance tumour control of radioresistant hypoxic tumours. Recent studies indicate that the formation of radical anions is a key step. Thus understanding the ionization reactions of radiosensitizers is crucial in evaluating the radiosensitization potential and in developing new and more effective drugs. The present study concentrates on the electronic structures of several important radiosensitizers such as nimorazole, 1-methyl-5-nitroimidazole, and 4(5)-nitroimidazole using gas phase synchrotron source X-ray photoemission spectroscopy and quantum mechanics. Detailed analysis of valence and core level spectra will be provided and discussed in the light of possible tautomerism in these compounds.
Keywords or phrases (comma separated) XPS, radiosensitizers, conformers, experiment and theory

Primary author


Prof. Feng Wang (Swinburne University of Technology) Prof. Kevin Prince (Elettra, Italy) Dr Linda Feketeováb (Melbourne) Dr Marawan Ahmeda (Swinburne) Prof. Michael Horsman (Aarhus University Hospital, Denmark)

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