Speaker
Description
Designer lipid colloids are being increasingly studied for the delivery of drugs and nutrients. These nanoparticles can have different internal nanostructures and different lipidic composition. Cyclopropanated derivatives of commonly used monoacylglycerols show substantial differences in self-assembled structures, and formations of nanostructured nanoparticles. Most remarkably, small differences in the hydrophobic tail affect the packing of the lipids, sufficient to alter the availability of the lipid headgroups to be hydrolysed by interfacial enzymes. We employed small angle X-ray scattering and acid/base titration at the Australian Synchrotron SAXS/WAXS beamline to monitor the nanostructural changes during hydrolysis and the digestion rate. These fundamental characteristics are of interest for the smart design of lipidic nanoparticles for drug or nutrients delivery.
Salvati Manni L. et al. (2021) J. Colloid Interface Sci. 588, 767-775
| Condition of submission | Yes |
|---|---|
| Pronouns | She/Her |
| Which facility did you use for your research | Australian Synchrotron |
| Presenter Gender | Woman |
| Level of Expertise | Early Career <5 Years |
