Ms
Ashley Hollings
(School of Molecular and Life Sciences, Curtin University, GPOBox U1987, Bentley Western Australia 6845, Australia. Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia 6102, Australia.)
Alzheimer’s disease is the most common form of dementia and poses significant health and economic concerns. Currently, the disease has no cure, and it is expected that over 1 million people could be affected by 2058 in Australia alone. The content and distribution of metals such as Fe, Cu, Zn is known to change in the ageing brain and thus, increased understanding of the mechanistic role of metal dis-homeostasis may illuminate new therapeutic strategies. The brain lateral ventricles, which play a role in controlling metal and ion transport, have shown increasing levels of copper surrounding their walls with ageing. As a redox active metal, copper can induce oxidative stress which is a process that occurs during Alzheimer’s disease onset and progression. Our research group has been interested in determining whether the age-related elevation of copper surrounding the lateral ventricles is inducing oxidative stress in that region. In this study, we have utilised X-Ray Absorption Spectroscopy (XAS) at the Stanford Synchrotron Radiation Lightsource to analyse different chemical forms of sulfur and measure oxidative stress by analysis of disulfides. Additionally, we used the infrared microscopy beamline at the Australian Synchrotron to identify whether any other markers of oxidative stress were present around the ventricles. Further insights into metal dis-homeostasis and its influence on other biochemical pathways, may help to reveal some of the neurochemical mechanisms involved in progression of Alzheimer’s disease. In turn, this may help pave the way for potential preventative or therapeutic models.
| Students Only - Are you interested in AINSE student funding |
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| Do you wish to take part in the Student Poster Slam |
Yes
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| Level of Expertise |
Student
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| Which facility did you use for your research |
Australian Synchrotron
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| Condition of submission |
Yes
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| Presenter Gender |
Woman
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Ms
Ashley Hollings
(School of Molecular and Life Sciences, Curtin University, GPOBox U1987, Bentley Western Australia 6845, Australia. Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia 6102, Australia.)
Dr
Mark Hackett
(School of Molecular and Life Sciences, Curtin University, GPOBox U1987, Bentley Western Australia 6845, Australia. Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia 6102, Australia.)
Dr
Mark Tobin
(Australian Nuclear Science and Technology Organisation, 800 Blackburn Road, Clayton, VIC 3168, Australia)
Dr
Annaleise Klein
(Australian Nuclear Science and Technology Organisation, 800 Blackburn Road, Clayton, VIC 3168, Australia)
Dr
Jitraporn Vongsvivut
(Australian Nuclear Science and Technology Organisation, 800 Blackburn Road, Clayton, VIC 3168, Australia)
Dr
Martin de Jonge
(Australian Nuclear Science and Technology Organisation, 800 Blackburn Road, Clayton, VIC 3168, Australia)
Dr
Sharon Bone
(Stanford Synchrotron Radiation Lightsource, Menlo Park, California, USA)
Dr
Samuel Webb
(Stanford Synchrotron Radiation Lightsource, Menlo Park, California, USA)
Dr
Virginie Lam
(Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia 6102, Australia. School of Public Health, Curtin University, Bentley, Western Australia 6102, Australia.)
Dr
Ryu Takechi
(Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia 6102, Australia. School of Public Health, Curtin University, Bentley, Western Australia 6102, Australia.)
Prof.
John Mamo
(Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia 6102, Australia. School of Public Health, Curtin University, Bentley, Western Australia 6102, Australia.)
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