Speaker
Description
Non-small-cell lung carcinomas are highly radioresistant and so, of potential interest for treatment with Microbeam Radiation Therapy. In the thoracic cavity, the therapeutic dose is limited largely by the heart; one of the most important organs of risk.
We developed an ex vivo protocol to study the acute response of the cardiac impulse conduction system to microbeam radiotherapy with high peak doses, combining physiology measurements in the Langendorff model of the isolated beating heart with world-leading real-time small volume dosimetry.
The study was performed in Hutch 2B of the Imaging and Medical Beam Line (IMBL) of the Australian Synchrotron.
The acute physiological response of the heart was measured for 60 minutes post-irradiation.
With no arrhythmia or ventricle pressure drop, results place the upper limit for normal functioning of the heart between 400 – 4,000 Gy
| Condition of submission | Yes |
|---|---|
| Which facility did you use for your research | Australian Synchrotron |
| Students Only - Are you interested in AINSE student funding | Yes |
| Presenter Gender | Man |
| Pronouns | He/Him |
| Level of Expertise | Student |
| Do you wish to take part in the Student Poster Slam | Yes |
