David Thal1
1 Monash University
Corresponding Author(s): david.thal@monash.edu
G protein-coupled receptors (GPCRs) are key cell-surface proteins that transduce external environmental cues into biochemical signals across the cell membrane. They are the largest superfamily of cell-surface receptors encoded by the human genome and are also the largest class of FDA approved drug targets....
T cells are a critical part of the immune response, that would determine the fate of an infection and disease outcome. Our Lab is focused on understanding how T cell engage with viral particles, called peptide antigens, that are presented by highly polymorphic molecules called Human Leukocyte Antigens (HLA). T cells have receptors on their surface called T cell receptor (TCR) that allow them...
Interferon regulatory factor 4 (IRF4) is a transcription factor (TF) that regulates the gene expression of immune cells including T cells and B cells. Due to its critical role in B and T cell development, IRF4 is linked directly to numerous immune-related disease conditions including B cell-related chronic lymphocytic leukemia (CLL) and adult T cell leukemia (ATL) (1). Structurally, IRF4...
The pandemic Coronavirus Disease 2019 (COVID19) caused by SARS-CoV-2 is a serious public health concern with global mortality reaching 1 million. Whilst the search for a vaccine is underway, there a several antiviral and antibody treatments being clinically evaluated to fill the “therapeutic gap”. The development of potential drugs requires an understanding of SARS-CoV-2 pathogenicity and...
Cytochrome c oxidase or mitochondrial respiratory chain complex IV catalyses the transfer of electrons from cytochrome c in the intermembrane space, to molecular oxygen in the matrix and therefore contributes to the proton gradient that drives mitochondrial ATP synthesis. Complex IV dysfunction is a significant cause of human mitochondrial disease. Complex IV requires the incorporation of...
From March 2020, the Australian Synchrotron joined the rest of Victoria in COVID-19 lockdown, severely limiting the access to beamlines by staff and users. The MX beamlines stayed operational under a COVID-19 Rapid Access scheme, developed to facilitate research into the SARS-Cov-2 virus. A number of user groups pivoted their research interests to include SARS-Cov-2 proteins, and human...
