Understanding protein-lipid interactions and the resulting protein structures is crucial for evolving food technology, biological and biomedical applications of nanomaterials. Knowledge regarding the effect of the multiple components in the system on the nanostructure, within the context of the application, is needed. Lyotropic liquid crystal design rules1 were developed and the effect of...
Biopharmaceuticals, including therapeutic proteins and peptides, represent the fastest growing class of new pharmaceuticals with application as treatments for auto-immune disorders, cancer and cardiovascular disease. Significant efforts have converged towards the design and development of more sophisticated delivery systems for protein-based pharmaceuticals, able to ensure controlled release...
Introduction: Digestion of the milk lipids in our intestines yields monoglycerides and fatty acids that self-assemble into a variety of liquid crystalline structures. This self-assembly process is species dependent,[1,2] suggesting an important role for these structures in infant nutrition. Our recent work on the SAXS/WAXS beamline has focussed on studying how the lipid compositions of...
Fluctuation x-ray scattering studies how the x-ray diffraction pattern changes as a small x-ray beam is scanned relative to the sample. The ensemble of diffraction patterns from different sample positions can reveal information about the local 3D structure in disordered materials. We have developed a fluctuation scattering technique called the pair-angle distribution function (PADF) method...
By correlating large ensembles of X-ray scattering data, fluctuation X-ray scattering can extract atomic and nanoscale structural information from a range of systems including colloidal glasses and crystals, liquid-crystal membranes, nanoparticles, and magnetic domains [1-4]. Real-space pair-angle distribution functions are higher order analogues of the basic pair-distribution functions and...