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SUMMARY:Drug-induced morphology transition of self-assembled glycopolymers
 : Insight into the drug-polymer interaction
DTSTART;VALUE=DATE-TIME:20181119T035000Z
DTEND;VALUE=DATE-TIME:20181119T041000Z
DTSTAMP;VALUE=DATE-TIME:20260809T071523Z
UID:indico-contribution-2484@events01.synchrotron.org.au
DESCRIPTION:Speakers: Cheng CAO (UNSW\, ANSTO)\nIt is often assumed that a
  hydrophobic drug will be entrapped in the hydrophobic environment of a mi
 celle. Little attention is usually drawn to the actual location of the dru
 g and the effect of the drug on properties. In this publication\, we show 
 how the chosen drug curcumin is not only unexpectedly located in the shell
  of the micelle\, but that the accumulation in the hydrophilic block can l
 ead to changes in morphology during self-assembly. A block copolymer poly(
 1-O-methacryloyl -β-D-fructopyranose)-b-poly(methyl methacrylate)\, Poly(
 1-O-MAFru)36-b-PMMA192\, was loaded with different amounts of curcumin. Th
 e resulting self-assembled nanoparticles were analyzed using TEM\, SAXS\, 
 and SANS. Initial microscopy evidence revealed that the presence of the dr
 ug induces morphology changes from cylindrical micelles (no drug) to polym
 ersomes\, which decreased in size with increasing amount of drug (Figure 1
 ). SAXS and SANS analysis\, supported by fluorescence studies\, revealed t
 hat the drug is interacting with the glycopolymer block. The drug did not 
 only influence the shape of the drug carrier\, but also the level of hydra
 tion of the shell. Increasing the amount of drug dehydrated the nanopartic
 le shell\, which coincided with a lower nanoparticle uptake by MCF-7 breas
 t cancer cells and non-cancerous Raw-264.7 cells. As a result\, we showed 
 that the drug can influence the behaviour of the nanoparticle in terms of 
 shape and shell hydration\, which could influence the performance in a bio
 logical setting (Figure 1). Although the depicted scenario may not apply t
 o every drug carrier\, it is worth evaluation if the drug will interfere i
 n unexpected ways\, for example\, when the drug locates on the surface and
  affects the internal structure of the nanocarrier.\n\nhttps://events01.sy
 nchrotron.org.au/event/84/contributions/2484/
LOCATION:AINSE Conference Centre New Illawarra Road Lucas Heights NSW 2234
  Australia
URL:https://events01.synchrotron.org.au/event/84/contributions/2484/
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