Structural Biology II
- Megan Maher (La Trobe University)
Dr Brett Collins (The University of Queensland, Institute for Molecular Bioscience)
Caveola membrane invaginations are a striking feature of many vertebrate cell types, and are critical for cell signaling, endocytosis and mechanotransduction. Their formation depends on the caveolins and the cavin peripheral membrane proteins (cavin1, cavin2, cavin3 and cavin4), although there is currently no atomic level information addressing the mechanisms that underpin caveola assembly....
76. A Two-pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic acid-based Inhibitors.
Dr Nyssa Drinkwater (Monash University)
Malaria is caused by parasites of the genus Plasmodium, with Plasmodium falciparum (Pf) causing the most deaths. The prevention and treatment of Pf malaria is becoming increasingly difficult due to the spread of drug resistant parasites. New therapeutics with a novel mode of action are desperately required. Two Plasmodium falciparum aminopeptidases, PfA-M1 and PfA-M17, play crucial roles in...
Ms Chen Gao (Structural Biology Laboratory and ACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, University of Melbourne, Melbourne, Vic, Australia)
Amyloid precursor protein (APP) is a type-I transmembrane protein with a large ectodomain (sAPP), a single transmembrane domain and a cytoplasmic tail. It is cleaved by beta- and gamma-secretases to generate amyloid-β (Aβ), a neurotoxic peptide implicated in Alzheimer’s disease (AD). APP dimerisation is closely linked to Aβ overproduction. It is also implicated in APP signalling as APP is...
Dr Stefan Hermans (St Vincent's Institute)
Dementia is the single greatest cause of disability in older Australians afflicting almost one in ten over the age of 65. In the absence of curative therapies, current treatments aimed at enhancing working memory target the cholinergic system and demonstrate limited efficacy, underpinning the need for a new class of cognitive enhancing drug. Insulin-regulated aminopeptidase (IRAP) is a...