BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//CERN//INDICO//EN
BEGIN:VEVENT
SUMMARY:Identification of Genes and Molecular Pathways Regulated by Synchr
 otron Microbeam Radiotherapy
DTSTART;VALUE=DATE-TIME:20141121T035500Z
DTEND;VALUE=DATE-TIME:20141121T041500Z
DTSTAMP;VALUE=DATE-TIME:20260711T043802Z
UID:indico-contribution-720@events01.synchrotron.org.au
DESCRIPTION:Speakers: Yuqing Yang (University of Melbourne)\nSynchrotron-g
 enerated microbeams radiotherapy (MRT) is a novel preclinical radiotherapy
 \,in which synchrotron-generated X-rays are segmented by a collimator\, pr
 oducing intense microbeams. MRT has been shown to be extremely well tolera
 ted by normal tissues including the central nervous system in animal model
 s when compared to conventional radiotherapy (CRT). The aim of this study 
 was to identify genes and molecular pathways differentially regulated by M
 RT versus CRT in vitro using cultured EMT6.5 cells. We hypothesized that g
 ene expression and molecular pathway changes after MRT are different from 
 those seen after CRT. We found that at 24 hr post-irradiation\, MRT exerts
  a broader regulatory effect on multiple pathways than CRT. MRT regulated 
 those pathways involved in gene transcription\, translation initiation\, m
 acromolecule metabolism\, oxidoreductase activity and signalling transduct
 ion in a different manner compared to CRT. We also found that MRT/CRT alon
 e\, or when combined with IFN-γ or LPS\, up-regulated expression of Ccl2\
 , Ccl5 or Csf2\, which are involved in immune cell recruitment. Our findin
 gs demonstrated differences in the molecular pathway for MRT versus CRT in
  the cultured tumour cells. Our findings are consistent with the notion th
 at radiation plays a role in recruiting tumour-associated immune cells to 
 the tumour. Our results also suggest that a combination of MRT/CRT with a 
 treatment targeting CCL2 or CSF2 could repress the tumour-associated immun
 e cell recruitment\, delay tumour growth and/or metastasis\, and yield bet
 ter tumour control than radiation alone.\n\nhttps://events01.synchrotron.o
 rg.au/event/3/contributions/720/
LOCATION: Conference Room AS
URL:https://events01.synchrotron.org.au/event/3/contributions/720/
END:VEVENT
END:VCALENDAR