20-21 November 2014
National Centre for Synchrotron Science
Australia/Melbourne timezone
Save the date: User Meeting 2015 - 26-27 November

Using synchrotron radiation to determine the X-ray structure and ct-DNA binding affinity of platinum(II) anticancer complexes

20 Nov 2014, 17:30
1h 30m
NCSS Exhibition Area ()

NCSS Exhibition Area

Australian Synchrotron 800 Blackburn Road Clayton VIC 3168
Board: 306


Mr Benjamin Pages (University of Western Sydney)


Platinum(II) anticancer complexes incorporating 2,2'-bipyridine (bpy), 4,4'-dimethyl-2,2'-bipyridine (44Me2bpy) and 2-(2'-pyridyl)quinoxaline (2pq) as polyaromatic ligands and cyclic diamines as ancillary ligands have been synthesised and were characterised via several methods including synchrotron radiation X-ray crystallography. The crystal structure of [Pt(44Me2bpy)(1S,2S-diaminocyclohexane)]2+ (44MEBSS) revealed a square planar coordination geometry similar to other complexes of this type whereas the complex [Pt(2pq)(1S,2S-diaminocyclohexane)]2+ (2PQSS) was distorted square planar.. The binding of 2PQSS and 44MEBSS to calf-thymus DNA (ct-DNA) was analysed using synchrotron radiation circular dichroism (SRCD) melting experiments and compared to similar complexes that incorporate 1,10-phenanthroline and dipyrido[3,2-f:2',3'-h]quinoxaline. The results revealed unexpected trends in DNA affinity relative to polyaromatic ligand size.
Keywords or phrases (comma separated) synchrotron radiation circular dichroism (SRCD) melting experiments

Primary author

Mr Benjamin Pages (University of Western Sydney)


Dr Feng Li (University of Western Sydney) Prof. Janice Aldrich-Wright (University of Western Sydney) Dr Nykola Jones (Department of Physics and Astronomy - Institute for Storage Ring Facilities, Aarhus University, Denmark) Dr Yingjie Zhang Zhang (ANSTO)

Presentation Materials

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