Speaker
Mr
Benjamin Pages
(University of Western Sydney)
Description
Platinum(II) anticancer complexes incorporating 2,2'-bipyridine (bpy), 4,4'-dimethyl-2,2'-bipyridine (44Me2bpy) and 2-(2'-pyridyl)quinoxaline (2pq) as polyaromatic ligands and cyclic diamines as ancillary ligands have been synthesised and were characterised via several methods including synchrotron radiation X-ray crystallography. The crystal structure of [Pt(44Me2bpy)(1S,2S-diaminocyclohexane)]2+ (44MEBSS) revealed a square planar coordination geometry similar to other complexes of this type whereas the complex [Pt(2pq)(1S,2S-diaminocyclohexane)]2+ (2PQSS) was distorted square planar.. The binding of 2PQSS and 44MEBSS to calf-thymus DNA (ct-DNA) was analysed using synchrotron radiation circular dichroism (SRCD) melting experiments and compared to similar complexes that incorporate 1,10-phenanthroline and dipyrido[3,2-f:2',3'-h]quinoxaline. The results revealed unexpected trends in DNA affinity relative to polyaromatic ligand size.
| Keywords or phrases (comma separated) | synchrotron radiation circular dichroism (SRCD) melting experiments |
|---|
Primary author
Mr
Benjamin Pages
(University of Western Sydney)
Co-authors
Dr
Feng Li
(University of Western Sydney)
Prof.
Janice Aldrich-Wright
(University of Western Sydney)
Dr
Nykola Jones
(Department of Physics and Astronomy - Institute for Storage Ring Facilities, Aarhus University, Denmark)
Dr
Yingjie Zhang Zhang
(ANSTO)
