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SUMMARY:Using Synchrotron Radiation Circular Dichroism (SRCD) to probe G-q
 uadruplex DNA-platinum(II) complex interactions
DTSTART;VALUE=DATE-TIME:20141120T063000Z
DTEND;VALUE=DATE-TIME:20141120T080000Z
DTSTAMP;VALUE=DATE-TIME:20260712T181930Z
UID:indico-contribution-692@events01.synchrotron.org.au
DESCRIPTION:Speakers: Janice Aldrich-Wright (University of Western Sydney)
 \nPlatinum(II) anticancer drugs\, such as cisplatin and carboplatin\, bind
  to DNA coordinately and have many limitations including poor effectivenes
 s against many cancer cell lines\, acquired resistance\, cross-resistance 
 as well as unwanted side effects. To overcome these limitations we have re
 cently synthesised dinuclear (2\,2':6'\,2''-terpyridine)-based complexes t
 hat are connected by thiol chains of varying length (with IC50 in L1210 ce
 lls). These compounds have demonstrated potent cytotoxicity in cancerous c
 ell lines and are thought to interact with DNA through π-stacking interac
 tions involving their terpyridine moieties. Small molecules that selective
 ly bind to G-quadruplex DNA (Q-DNA) have been shown to stabilise these str
 uctures\, and so Q-DNA represents a potential biological target for the su
 ppression of telomerase activity. Here we present SRCD-based melting studi
 es of the binding of our platinum(II) complexes to Q-DNA.\n\nhttps://event
 s01.synchrotron.org.au/event/3/contributions/692/
LOCATION: NCSS Exhibition Area
URL:https://events01.synchrotron.org.au/event/3/contributions/692/
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