20-21 November 2014
National Centre for Synchrotron Science
Australia/Melbourne timezone
Save the date: User Meeting 2015 - 26-27 November

Using Synchrotron Radiation Circular Dichroism (SRCD) to probe G-quadruplex DNA-platinum(II) complex interactions

20 Nov 2014, 17:30
1h 30m
NCSS Exhibition Area ()

NCSS Exhibition Area

Australian Synchrotron 800 Blackburn Road Clayton VIC 3168
Board: 302


Prof. Janice Aldrich-Wright (University of Western Sydney)


Platinum(II) anticancer drugs, such as cisplatin and carboplatin, bind to DNA coordinately and have many limitations including poor effectiveness against many cancer cell lines, acquired resistance, cross-resistance as well as unwanted side effects. To overcome these limitations we have recently synthesised dinuclear (2,2':6',2''-terpyridine)-based complexes that are connected by thiol chains of varying length (with IC50 in L1210 cells). These compounds have demonstrated potent cytotoxicity in cancerous cell lines and are thought to interact with DNA through π-stacking interactions involving their terpyridine moieties. Small molecules that selectively bind to G-quadruplex DNA (Q-DNA) have been shown to stabilise these structures, and so Q-DNA represents a potential biological target for the suppression of telomerase activity. Here we present SRCD-based melting studies of the binding of our platinum(II) complexes to Q-DNA.
Keywords or phrases (comma separated) Synchrotron Radiation Circular Dichroism (SRCD) melting studiesof G-Quadraplex DNA

Primary author

Prof. Janice Aldrich-Wright (University of Western Sydney)


Dr Benjamin Harper (University of Western Sydney) Mr Benjamin Pages (University of Western Sydney) Mr Dale Ang (University of Western Sydney) Dr Nykola Jones (Department of Physics and Astronomy - Institute for Storage Ring Facilities, Aarhus University, Denmark) Prof. Ramon Vilar (Imperial College London, United Kingdom) Dr Søren Hoffmann (Department of Physics and Astronomy - Institute for Storage Ring Facilities, Aarhus University, Denmark)

Presentation Materials

There are no materials yet.
Your browser is out of date!

Update your browser to view this website correctly. Update my browser now