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SUMMARY:Comparison of dose deposition patterns of multi-slit versus single
 -slit collimators in synchrotron MRT and their effect on 9L cells
DTSTART;VALUE=DATE-TIME:20141120T063000Z
DTEND;VALUE=DATE-TIME:20141120T080000Z
DTSTAMP;VALUE=DATE-TIME:20260722T171656Z
UID:indico-contribution-689@events01.synchrotron.org.au
DESCRIPTION:Speakers: Michael Lerch (CMRP\, UoW)\nResults of quantitative 
 evaluation and comparison of dose deposition patterns and radiobiological 
 effects in synchrotron microbeam radiotherapy (MRT) - in particular\, the 
 inter-microbeam "valley" dose - for six beam geometries and three differen
 t in-beam dose values are presented. The X-Tream dosimeter and Gafchromic 
 film have been used to quantitatively compare the dose distribution result
 ing from step-and-shoot single versus multi-slit collimation for two of th
 e six beam geometries in order to validate the use of the single-slit appr
 oach for the other four geometries. Radiobiological effects have been asse
 ssed by evaluating post-irradiation cell survival fractions on cultured 9L
  gliosarcoma cells. \n\nPreliminary results from our allocated beamtime at
  the Australian synchrotron show that valley doses obtained with single-sl
 it step-and-shoot collimation are between 3 and 10% lower than in multi-sl
 it collimation with the same beam width and peak-to-peak distance. The bio
 logical effects of any difference in spatial and temporal dose deposition 
 patterns were also investigated by irradiating in vitro 9L gliosarcoma cel
 ls (at a depth of 2 cm in water\, surrounded by solid water) using both be
 am delivery methods. At the time of writing this abstract\, the irradiated
  cells are in incubation and their colony formation abilities will be asse
 ssed in two weeks.\n\nhttps://events01.synchrotron.org.au/event/3/contribu
 tions/689/
LOCATION: NCSS Exhibition Area
URL:https://events01.synchrotron.org.au/event/3/contributions/689/
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