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SUMMARY:Structural characterization of SARS-Cov-2 spike derived peptides p
 resented by the Human Leukocyte Antigen A*29:02.
DTSTART;VALUE=DATE-TIME:20211125T074700Z
DTEND;VALUE=DATE-TIME:20211125T074800Z
DTSTAMP;VALUE=DATE-TIME:20260814T130227Z
UID:indico-contribution-4365@events01.synchrotron.org.au
DESCRIPTION:Speakers: Lawton Murdolo (La Trobe University)\nThe rapid emer
 gence of SARS-Cov-2 out of Wuhan\, China\, in late 2019 has resulted in th
 e current outbreak that has crippled social and economic development world
 wide. With over four million deaths\, significant efforts are being made t
 o generate a viable treatment option. It has been well established that T 
 lymphocytes destroy infected cells. These T cells also produce long lastin
 g immunity through the proliferation of memory cells which recognize futur
 e viral invasion.\n\nActivation of T lymphocytes is achieved through the r
 ecognition of Human Leukocyte Antigens (HLA) surface receptors on infected
  cells. These HLA molecules present viral peptides to T cells which are ab
 le to recognize and activate against these antigens. \n\nHowever\, due to 
 the highly polymorphic nature of HLA molecules\, it remains unclear how di
 fferent peptides bind to the vast number of HLA molecules affect the stimu
 lation of the adaptive immune response. \n\nThe focus of this project is o
 n a singular HLA\,  HLA-A*29:02\, found in approximately 3% of the world
 ’s population. We wish to structurally analyse various peptides presente
 d by HLA-A*29:02 derived from the SARS-Cov-2 spike protein and determine h
 ow COVID-19 variants and their mutations might different in their presenta
 tion to T cells. \n\nThrough the use of X-ray crystallography\, we will ga
 in deeper insights into how theses peptides are presented. This will furth
 er our understanding of how our own immune system responds to these antige
 ns and may also help to in designing long lasting therapies such as peptid
 e vaccines.\n\nhttps://events01.synchrotron.org.au/event/146/contributions
 /4365/
LOCATION:Online
URL:https://events01.synchrotron.org.au/event/146/contributions/4365/
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