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SUMMARY:SPACE RADIATION AND INDIVIDUAL RADIOSENSITIVITY- ANSTO CAS & HUMAN
  HEALTH IN AIR BEAM EXPERIMENTS
DTSTART;VALUE=DATE-TIME:20211126T025000Z
DTEND;VALUE=DATE-TIME:20211126T030500Z
DTSTAMP;VALUE=DATE-TIME:20260814T120832Z
UID:indico-contribution-4267@events01.synchrotron.org.au
DESCRIPTION:Speakers: Melanie Lydia Ferlazzo (ANSTO)\nRadiation exposure i
 s a major limiting factor for long duration manned space flights. \nRadiat
 ion protection standards are based on the assumption that individuals are 
 equally resistant to ionizing radiation. However\, for over a century\, th
 ere is evidence that humans do not respond equally to radiation. Particula
 rly\, the studies of secondary effects post-radiotherapy have shown a grea
 t variability among individuals. More specifically\, large discrepancies a
 mong astronauts after the same flight were observed. Recently\, from a col
 lection of hundreds of fibroblast cell lines derived from patients sufferi
 ng from genetic disease or post-radiotherapy radiosensitivity\, we have sh
 own that the delay in the nucleoshuttling of the ATM protein may cause a l
 ack of double strand break (DSB) recognition\, incomplete DSB repair and r
 adiosensitivity.  Interestingly\, the model of the ATM nucleoshuttling was
  shown to be relevant not only for low-dose and repeated exposures\, but a
 lso for high-LET particles\, which renders this model compatible with spac
 e radiation exposure scenarios. Lastly\, this model could lead to a novel 
 approach for radiation protection\, consisting of interventions to acceler
 ate ATM nucleoshuttling.  Such an approach may help in developing efficien
 t countermeasures that could assist with manned space flights. In 2019-202
 1\, teams from ANSTO CAS and Human Health have been collaborating to adapt
  the ANTARES beamline for in air irradiation of living matter and study th
 e effects of secondary radiation produced by interraction of cosmic and ga
 lactic rays with spacecraft shielding. DNA repair and mitochondrial activi
 ty processes will be studied.\n\nhttps://events01.synchrotron.org.au/event
 /146/contributions/4267/
LOCATION:Online
URL:https://events01.synchrotron.org.au/event/146/contributions/4267/
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