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SUMMARY:Structures of biliary micelles during solubilisation of lipids mim
 icking the digestion products of human and bovine milk
DTSTART;VALUE=DATE-TIME:20211124T002000Z
DTEND;VALUE=DATE-TIME:20211124T003500Z
DTSTAMP;VALUE=DATE-TIME:20260814T125755Z
UID:indico-contribution-4258@events01.synchrotron.org.au
DESCRIPTION:Speakers: Andrew Clulow (ANSTO Australian Synchrotron)\nMilk i
 s our sole source of nutrition for the first six months of life and milk l
 ipids carry fat-soluble nutrients through the gut as well as providing mos
 t of the energy we consume with milk. The digestion and absorption of lipi
 ds\, predominantly triglycerides\, and entrained nutrients is therefore im
 portant for survival and growth. Milk triglycerides are regarded amongst t
 he most chemically complex mixtures\, their composition is species-depende
 nt and determines the mixture of fatty acids and monoglycerides that form 
 during their digestion. Most lipid digestion takes place in the small inte
 stines where bile salts mixed with phospholipids in the intestinal fluids 
 form a colloidal sink into which the poorly-soluble digestion products can
  partition and be absorbed at the intestinal walls. This work describes at
 tempts to simulate how the structures of biliary micelles change when they
  absorb milk digestion products under intestinal conditions. Mixtures of f
 atty acids and monoglycerides were prepared to mimic the digestion product
 s of human and bovine milk. The chemical complexity of the mixtures was va
 ried by including between four and eight different lipid chain types in th
 e digestion product mixtures. The effect of pH on micelle structure was al
 so studied within the range of pH 6.4-7.7\, consistent with the increase i
 n pH along the intestinal tract. The structural differences when these com
 plex lipid mixtures were solubilised by bile salt/phospholipid micelles we
 re identified using the SAXS/WAXS beamline at the ANSTO Australian Synchro
 tron. The lipid composition was found to be a primary driver of micelle sh
 ape and size\, with pH having a secondary affect in reducing aggregate for
 mation at higher pH.\n\nhttps://events01.synchrotron.org.au/event/146/cont
 ributions/4258/
LOCATION:Online
URL:https://events01.synchrotron.org.au/event/146/contributions/4258/
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