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SUMMARY:Biocompatible ionic liquids as designer solvents for the formation
  of non-lamellar lyotropic liquid crystalline nanoparticles as drug delive
 ry vehicles
DTSTART;VALUE=DATE-TIME:20211125T065900Z
DTEND;VALUE=DATE-TIME:20211125T070000Z
DTSTAMP;VALUE=DATE-TIME:20260306T082513Z
UID:indico-contribution-4213@events01.synchrotron.org.au
DESCRIPTION:Speakers: Mohamad El Mohamad (RMIT university)\nIonic liquids 
 (ILs) have emerged as a remarkable class of green solvents with unique cha
 racteristics\, and feasible task-specific tailoring of their properties. T
 he application of ILs has extended to facilitate amphiphile self-assembly.
  ILs not only support the self-assembly of amphiphiles\, they can also be 
 used as designer solvents(1). \nLipid amphiphiles can assemble into a wide
  range of lyotropic liquid crystalline mesophases possessing unique highly
  ordered multidimensional structures. The bulk phases can be further broke
 n into nanoparticle dispersions (LCNPs)\,for examples cubosomes and hexoso
 mes\, that are characterised by their high surface to volume ratio. These 
 particles are receiving growing interest due to their great potential as d
 rug delivery vehicles for both hydrophilic and hydrophobic drugs(2). \nOur
  recent small angle X ray scattering (SAXS) results revealed a wide range 
 of LCNPs such as cubosomes and hexosomes obtained in various biocompatible
  ILs-water solvents. A strong correlation exists between the pH of the sol
 utions and the adapted phases.\n\nReferences:\n1.	Zhai\, J.\; Sarkar\, S.\
 ; Tran\, N.\; Pandiancherri\, S.\; Greaves\, T. L.\; Drummond\, C. J.\, Tu
 ning Nanostructured Lyotropic Liquid Crystalline Mesophases in Lipid Nanop
 articles with Protic Ionic Liquids. The Journal of Physical Chemistry Lett
 ers 2021\, 12 (1)\, 399-404.\n2.	Zhai\, J.\; Fong\, C.\; Tran\, N.\; Drumm
 ond\, C. J.\, Non-Lamellar Lyotropic Liquid Crystalline Lipid Nanoparticle
 s for the Next Generation of Nanomedicine. ACS Nano 2019\, 13 (6)\, 6178-6
 206.\n\nhttps://events01.synchrotron.org.au/event/146/contributions/4213/
LOCATION:Online
URL:https://events01.synchrotron.org.au/event/146/contributions/4213/
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