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SUMMARY:Analysis of Thermoresponsive Dextrans via Small-Angle X-ray Scatte
 ring
DTSTART;VALUE=DATE-TIME:20211125T073000Z
DTEND;VALUE=DATE-TIME:20211125T073100Z
DTSTAMP;VALUE=DATE-TIME:20260310T132450Z
UID:indico-contribution-4210@events01.synchrotron.org.au
DESCRIPTION:Speakers: Sarah Otto (University of South Australia)\nThermore
 sponsive polymers have gained significant interest over recent years due t
 o their potential use in a wide range of applications\, including drug del
 ivery\, cell therapies\, pharmaceuticals\, tissue engineering\, and minera
 l processing [1]. Of particular interest are thermoresponsive polysacchari
 des\, which are generally biocompatible and biodegradable\, unlike their s
 ynthetic counterparts. This is particularly important when considering bio
 medical applications\, such as drug delivery\, as biodegradability allows 
 for the clearance of the drug delivery system from the body and can help t
 o facilitate drug release. We have developed a novel family of thermorespo
 nsive polysaccharides with tunable transition temperatures via functionali
 sation of non-thermoresponsive dextran with a series of alkylamides [2]. B
 y altering the composition and degree of substitution of the alkylamide gr
 oups on the dextran backbone\, the temperature at which phase transition o
 ccurs can be tuned. Upon heating\, solutions of thermoresponsive dextrans 
 undergo a reversable phase transition to afford colloidal suspensions. The
  nature of the solution-to-colloid transition was investigated by UV-visib
 le spectrophotometry to determine the transition temperature and hystereti
 c effects\, and via dynamic light scattering to determine changes in parti
 cle size and dispersity. To further interrogate the phase transitions and 
 conformational changes occurring upon heating and cooling\, Synchrotron sm
 all-angle X-ray scattering (SAXS) was conducted as a function of temperatu
 re. Taken together\, these results provide a fundamental platform to furth
 er study the behaviour of these novel thermoresponsive dextrans when appli
 ed to specific applications\, such as drug delivery or mineral processing.
   \n1.	Graham\, S\, et al.\, 2019\, Carbohydrate Polymers\, 207\, p.143-15
 9.\n2.	Otto\, S\, et al.\, 2021\, Carbohydrate Polymers\, 254\, p.117280.\
 n\nhttps://events01.synchrotron.org.au/event/146/contributions/4210/
LOCATION:Online
URL:https://events01.synchrotron.org.au/event/146/contributions/4210/
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