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SUMMARY:Enhancing synchrotron modulated Microbeam Radiation Therapy in viv
 o with novel high Z nanoparticles
DTSTART;VALUE=DATE-TIME:20211125T064100Z
DTEND;VALUE=DATE-TIME:20211125T064200Z
DTSTAMP;VALUE=DATE-TIME:20260718T054520Z
UID:indico-contribution-4205@events01.synchrotron.org.au
DESCRIPTION:Speakers: Sarah Vogel (University of Wollongong)\nWith limited
  improvement in brain cancer patient survival in the last 30 years\, the s
 earch for a treatment strategy that is targeted and effective continues. T
 his study is harnessing the unique properties of synchrotron radiation for
  anti-cancer radiotherapy. The Imaging and Medical Beamline (IMBL) at the 
 ANSTO Australian Synchrotron (AS) offers the possibility to perform pre-cl
 inical synchrotron radiation trials using extremely high dose-rates\, spar
 ing normal tissue whilst delivering large doses to the tumour site. This s
 tudy focused on patient specific treatments combining Microbeam Radiation 
 Therapy (MRT) with novel high Z nanoparticles (NPs)\, and was the largest 
 rodent survival study utilising nanoparticle enhancement ever undertaken a
 t AS. Thulium oxide NPs (Z=69) are a promising sensitising and imaging age
 nt with limited cytotoxicity and proven synchrotron enhancement. 32 Fische
 r 344 rats were inoculated with 9L gliosarcoma in the right caudate nucleu
 s of the brain. 11 days later\, the rats were imaged with Computed Tomogra
 phy (CT) to locate the tumour in relation to bony anatomy. The following d
 ay\, nanoparticles were injected directly to the tumour of each rat. Using
  the CT scans\, the rats were aligned in-beam\, and a bolus was placed ove
 r the irradiation site. One radiation fraction was given to different trea
 tment groups at valley doses of 8\, 14 or 15Gy\, with a radiation field of
  8mm by 8mm and microbeams produced using the 4T magnet and Al/Al filtrati
 on. Utilising a heavily improved oedema protocol\, seizure symptoms and ad
 verse events immediately post MRT were significantly reduced. Overall surv
 ival compared to rodents with MRT alone was found to be improved when cons
 idering the tumour to brain volume.\n\nhttps://events01.synchrotron.org.au
 /event/146/contributions/4205/
LOCATION:Online
URL:https://events01.synchrotron.org.au/event/146/contributions/4205/
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