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SUMMARY:Structural basis of higher-order assembly formation in Toll-like r
 eceptor 1\,2 and 6 signaling pathway
DTSTART;VALUE=DATE-TIME:20211125T073500Z
DTEND;VALUE=DATE-TIME:20211125T073600Z
DTSTAMP;VALUE=DATE-TIME:20260306T092005Z
UID:indico-contribution-4202@events01.synchrotron.org.au
DESCRIPTION:Speakers: YAN LI (The University of Queensland)\nInnate immuni
 ty represents a typical and widely distributed form of immunity. Innate im
 mune responses are the first line of defense against pathogens\, which can
  help destroy invaders invertebrate animals\, invertebrates\, and plants. 
 The innate immune system recognizes microorganisms via pattern-recognition
  receptors (PRRs). The family of Toll-like receptors (TLRs) is a distinct 
 group of PRRs. They detect the microbial components known as pathogen-asso
 ciated molecular patterns (PAMPs)\, activate downstream transcription fact
 ors such as nuclear factor-κB (NF-κB)\, resulting in a pro-inflammatory 
 response. 10 TLRs have been identified in the human TLR family. In humans\
 , TLR2 can form heterodimers with TLR1 and TLR6 when binding different typ
 es of ligands. The cytoplasmic Toll/interleukin-1 receptor (TIR) domain ca
 n be found in all TLRs and is responsible for transmitting extracellular s
 ignals to intracellular cytoplasmic TIR domain-containing adaptor proteins
  through TIR: TIR domain interactions\, thus initiating downstream signali
 ng. Two TIR-domain containing adaptor proteins\, Myeloid differentiation p
 rimary response 88 (MyD88) and MyD88 adaptor-like (MAL) mediate downstream
  signaling in the TLR2-TLR1/6 signaling pathway. It has been previously de
 monstrated that higher-order assembly formation occurs in the TLR4 signali
 ng pathway. The mechanism\, which is known as signaling by cooperative ass
 embly formation (SCAF)\, may occur in all TLR signal transduction. To date
 \, the transduction mechanisms of TLR2-TLR1/6 signaling are still unclear.
  This research aims to determine the structural basis of higher-order asse
 mblies formed by TIR domains with a focus on assemblies in the TLR2-TLR1/6
  signaling.\n\nhttps://events01.synchrotron.org.au/event/146/contributions
 /4202/
LOCATION:Online
URL:https://events01.synchrotron.org.au/event/146/contributions/4202/
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