BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//CERN//INDICO//EN
BEGIN:VEVENT
SUMMARY:SNAKE VENOM-CONTRLLED 3D FIBRIN ARCHITECTURE REVEALED BY SANS/USAN
 S DICTATES FIBROBLAST DIFFERENTATION
DTSTART;VALUE=DATE-TIME:20211125T072700Z
DTEND;VALUE=DATE-TIME:20211125T072800Z
DTSTAMP;VALUE=DATE-TIME:20260310T123928Z
UID:indico-contribution-4197@events01.synchrotron.org.au
DESCRIPTION:Speakers: Zhao Wang (1Australian Institute for Bioengineering 
 and Nanotechnology\, The University of Queensland\, Australia.)\nFibrin is
  the founding matrix after injury\, delivering the key biophysical cues to
  promote wound healing in a timely and coordinated manner. The effect of t
 he fibrin architecture on wound healing hasn’t been studied due to a lac
 k of control over the enzyme-catalyzed polymerization of the fibrin networ
 k in vitro. Here\, we establish a new defined snake venom-controlled fibri
 n system with precisely and independently controlled architectural and mec
 hanical properties. By utilising combined small-angle neutron scattering (
 SANS) and ultra-small angle neutron scattering (USANS) techniques\, we cha
 racterize the full-scale architectural properties of the new system from t
 he internal structure of the individual fibres to the structure of the fib
 rin networks and compare them to super-resolution optical methods. This ve
 ry precise set of neutron scattering data confirms our full control over t
 he network’s architectural features\, which serves as a foundation for t
 he application of this defined system. The subsequent cell differentiation
  studies reveal that fibrin architecture has prevailing control over fibro
 blast spreading phenotypes and long-term myofibroblast differentiation. Th
 ese findings implicate matrix architecture as a key activator of fibroblas
 t differentiation and provide new biophysical strategies in the design of 
 biomaterials to promote scarless wound healing.\n\nhttps://events01.synchr
 otron.org.au/event/146/contributions/4197/
LOCATION:Online
URL:https://events01.synchrotron.org.au/event/146/contributions/4197/
END:VEVENT
END:VCALENDAR